The Department of Anaesthesia and Pain Management has a proud history of quality research. 

A variety of research is undertaken within the department including basic research, small research studies of various design conducted by supervised medical students, as well as major international multi-centre clinical trials.

Prof Kate LeslieHead of Research
A/Prof Andrew BjorkstenSenior Scientist


  • Prof Kate Leslie coordinates large multicentre trials endorsed by the Australian and New Zealand College of Anaesthetists Clinical Trial Network
  • A/Prof Malcolm Hogg is involved in pain medicine research
  • Dr Robyn Gillies and A/Prof Andrew Bjorksten continue to investigate the genetics of malignant hypertension
  • Prof Colin Royse major research interests are in echocardiography, cardiac outcomes for cardiac surgery and quality of recovery after surgery. Prof Royse is also the co-director of the Ultrasound Education Group in the Department of Surgery, University of Melbourne

Research fellow

The department maintains a research position for a provisional fellow. The position is half time research and half time clinical.

University affiliation

The department continues its close collaboration with the Department of Pharmacology, University of Melbourne.

Current research projects

PADDI Trial Perioperative administration of Dexamethasone and Infection.NHMRC grant $4.6 million


ROCKet Trial

Reduction of chronic post-surgical pain with Ketamine

NHMRC $4.82 million

The Chewy StudyC​hewing gum for the treatment of post-operative nausea and vomiting

ANZCA Research Foundation $70,000,

RMH Foundation $25,000

Balanced Anaesthesia StudyInfluence of anaesthetic depth on patient outcomes after major surgeryNHMRC $2.89 millionFollow up
RELIEF Trial Restrictive versus liberal fluid therapy in major abdominal surgery Completed
METSMeasurement of exercise tolerance for surgery study, and using the six-minute walk test to predict the quality of recovery and disability-free survival following major non-cardiac surgery Completed
ENIGMA-I TrialAvoidance of nitrous oxide for patients undergoing major surgery Completed

Safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery


Nitrous oxide and serious morbidity and mortality in the POISE trial

Neuraxial block, death and serious cardiovascular morbidity in the POISE trial


Aspirin in patients undergoing non-cardiac surgery

Clonidine in patients undergoing non-cardiac surgery

B-aware StudyBispectral index monitoring to prevent awareness during anaesthesia Completed

Clinical trial networks

We participate in Australian and New Zealand College of Anaesthetists Clinical Trial Network trials.