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Kurz, A. F., Lautenschlager, N. T.
In older adults who are developing Alzheimer-typical pathology but do not experience any symptoms-a condition termed " preclinical" Alzheimer's disease-the individual prognostic value of current biomarkers is low. Only a minority of those who have positive findings on biomarkers in the cerebrospinal fluid or upon brain imaging experience cognitive decline within 3-5 years.