Teams at two of Melbourne’s leading research and medical institutes are developing high-tech solutions to rapidly test for drugs and better treat patients presenting to hospital.

The researchers from the Colonial Foundation Healthy Ageing Centre - a collaboration between the Royal Melbourne Hospital and WEHI - are using mass spectrometry technology to quickly determine the presence of other medication or drugs that may interfere with their treatment.

This is important to ensure they are given the correct treatment - and the impact of any previous medication or drugs are mitigated.

Mass spectrometry technology works by using charged particles, or ions, to identify and measure chemicals in a sample. This, the team found, is more accurate than current testing methods, which use a biochemical test called immunoassays that may sometimes give false positives.

Colonial Foundation Healthy Ageing Centre (WEHI) researchers
Associate Professor Andrew Webb, Associate Professor Cherie Chiang and Dr Mustafa Ayhan of the Colonial Foundation Healthy Ageing Centre

In a recent study, published in the Medical Journal of Australia (MJA), the Colonial Centre team found that using traditional testing methods, a common prostate cancer drug could interfere with testing for another common heart failure medication and lead to a patient returning a false toxic result.

But by using mass spectrometry technology to complete the same test, this interference was able to be picked up and mitigated.

As a result, the patient avoided unnecessary treatment, and clinicians were able to focus on and treat the patient’s actual issue.

Head of Chemical Pathology at the RMH and researcher at the Colonial Centre, A/Prof Cherie Chiang, said having a fast, reliable and accurate reading is essential to providing great patient care.

“This new-age technology is enabling our teams to provide more specific results, and therefore treatment options, to our clinicians in real-time,” A/Prof Chiang said.

“As a result, we can provide patients with more personalised treatment plans and greater care.”

She said the next steps were to “expand our testing menu so more patients can potentially benefit from this new technology”.

The move is part of a shift towards personalised medicine - which centres around testing and tailoring treatment to a patient's specific needs.

Mobile Stroke Unit with Ambulance Victoria paramedic and the RMH Stroke team
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