The main purpose of this study is to track the cognitive, lifestyle and psychological markers of a large group of community-based middle-aged adults (40-65 years inclusive) over five years online, in relation to genetic risk factors that are shown to increase risk of Alzheimer’s disease dementia in older adults.
An early feasibility study of the safety of the Stentrode™ device in participants with loss of motor function due to paralysis from spinal cord injury, motor neuron disease, stroke, muscular dystrophy or loss of limbs.
We are looking for people with Crohn's Disease to participate in a study to determine the safety and effictiveness of a new study medication, guselkumab.
Guselkumab is made in the laboratory and is a fully human monoclonal antibody. An antibody is something that targets and kills foreign objects in the body - in this case, small proteins that are released by cells and affect the behaviour of other cells. This antibody, guselkumab, recognizes and blocks a specific small protein, IL-23, which is important in immune and inflammatory processes.
The ColoSTAT® test is being developed to provide an alternative option for people to undergo a colorectal cancer (CRC) screening test but for clinical, personal or cultural reasons, are unwilling or unable to use a stool test or are reluctant to undergo more invasive and costly procedures such as colonoscopy and sigmoidoscopy.
ColoSTAT® involves the collection of a blood sample, rather than stool, to assess the presence of components in the blood which, when assessed using a specifically designed algorithm, provide a CRC risk score. The algorithm uses the results from the blood test and incorporates other CRC risk factors, such as family history and lifestyle factors to determine this risk rating.
The purpose of this research is to find out whether the study medication denosumab can help prevent breast cancer in women with a BRCA1 mutation. The research also aims to find out whether denosumab decreases the risk of developing ovarian cancer or other types of cancer, study the safety of using denosumab, and study its effect on bone health.
The study is a randomised, double-blind, placebo-controlled study. This means that participants will receive an injection of either denosumab or placebo (no drug) every 6 months for 5 years. Participants will need to visit their study doctor every 6 months while receiving the medication and will continue to be checked by their study team every 12 months for a further 5 years (total of 10 years).
SKY-D is investigating whether ketamine is an effective treatment for young people with depression.
We are inviting young people aged 16 to 25 years, with moderate-to-severe depression, to take part in this research. Participants will divided into two groups. One group will receive a low dose of ketamine once a week for four weeks. The other group will receive a low dose of another medication, called midazolam, once a week for four weeks.
We hope that the results of this study will help us to provide the best possible care in the future for young people with depression.
Anticipated date that enrolment will close: November 2022
The purpose of this study is to compare the effects, good or bad, of combination immunotherapy (atezolizumab plus bevacizumab) versus observation (not receiving any treatment) on participants with completely resected or ablated hepatocellular cancer (HCC) who are at high risk for disease recurrence. In this study, patients will receive either atezolizumab plus bevacizumab or no treatment.
Both mania and psychosis can involve changes to a person’s mood, thinking, and behaviour and can impact a person’s social life and participation in work or education. These mental health conditions not only affect the person who has the disorder but also the lives of family members and friends who help support them.
By completing this survey, you will be contributing to a better understanding of caregiver and sibling experiences. This information will be particularly helpful for working out ways to better support caregivers and siblings.