Pathology handbook

BRAF

Test Code:

BRAF

Tube Colour:

Tissue Blocks / Unstained Slides

Department:

Molecular

Pseudonyms:

BRAF Mutation Detection

Collection Requirements:

Paraffin Embedded Tissues Blocks or Unstained Slides

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 10 business days

Requires own tube?:

Internal Spec Code:

Block or Slides

Fee:

Contact reference laboratory directly for current fee.

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

Testing performed at Peter MacCallum Cancer Centre Sections are prepared by Anatomical Pathology, RMH For establishment of BRAF V600 mutation status in tumour tissue prior to dabrafenib or vemurafenib therapy in a patient with unresectable stage III or stage IV metastatic cutaneous melanoma, requested by or on behalf of the treating specialist

BRCA1 Gene Analysis by MLPA

Test Code:

BR1m

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

MLPA for BRCA1, Breast cancer type 1 susceptibility gene

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

Molecular Pathology, RMH MUST be notified by phone (03 9342 7991) for all URGENT requests

Download 1

(DOC,25 KB)

BRCA1 Gene Predictive Analysis

Test Code:

BR1P

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Breast cancer type 1 susceptibility gene, predictive

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

1. Two indepedently collected EDTA tubes, greater than 15 minutes apart are required 2. Only Family Cancer Clinic requests will be processed 3. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

BRCA2 Gene Analysis by MLPA

Test Code:

BR2m

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

MLPA for BRCA2, Breast cancer type 2 susceptibility gene

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

Molecular Pathology, RMH MUST be notified by phone (03 9342 7991) for all URGENT requests

Download 1

(DOC,25 KB)

BRCA2 Gene Predictive Analysis

Test Code:

BR2P

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Breast cancer type 2 susceptibility gene, predictive

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

CSF Alzheimer's Screen

Test Code:

ADcsf

Tube Colour:

10mL yellow top

conical base

sterile polypropylene tube.

Department:

Molecular

Pseudonyms:

Amyloid beta 1-42 | _x000D__x000D_Phospho-tau (P-tau) | _x000D__x000D_Total tau (T-tau)_x000D__x000D_

Collection Requirements:

>2mL CSF collected directly into polypropylene tube |_x000D__x000D_Last collection required to minimise contamination |_x000D_ _x000D_Transport within 24 hours of lumbar puncture (ambient temperature) otherwise spin (10min at 2000g within 2 hour of collection) & freeze at -20oC, and transport on dry ice

Reference Range:

T-tau (total tau) protein <358pg/mL, | P-tau (Phospho-tau) protein <75pg/mL, | Amyloid beta 1-42 protein >647pg/mL

Availability:

Fortnightly turn around time

Requires own tube?:

Yes

Internal Spec Code:

ADF

Fee:

AUD $250 not Medicare rebatable for three proteins, $200 for any two proteins, $150 for any single protein

Reference Laboratory:

National Dementia Diagnostics Laboratory (NDDL)The Florey Institute Of Neuroscience And Mental HealthKenneth Myer BuildingThe University Of Melbourne

Laboratory:

Molecular Pathology

Black top 10mL tubes can NOT be used. _x000D__x000D_Tubes are available from FMIS Supplier Item No: 62.9924.284 (HPVC-042) Tube Centrifuge Sarstedt PolyPropylene 10mL 100X16MM conical base with graduations yellow polyethylene screw cap fitted _x000D__x000D_ _x000D__x000D_

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(PDF,410.03 KB)

Familial Adenomatis Polyposis (FAP)

Test Code:

FAP

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Familial Adenomatis Polyposis

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 6 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Victorian Clinical Genetics Services (VCGS)Royal Children's HospitalLevel 4, East Building50 Flemington RoadParkville, Vic 3052tel 03 8341 6201fax 03 8341 6390

Laboratory:

Molecular Pathology

This is an Urgent referral. Non-FCC requests will not be accepted

Hereditary nonpolyposis colorectal cancer (HNPCC)

Test Code:

HNPCC

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

HNPCC, Hereditary nonpolyposis colorectal cancer gene

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 6 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Victorian Clinical Genetics Services (VCGS)Royal Children's HospitalLevel 4, East Building50 Flemington RoadParkville, Vic 3052tel 03 8341 6201fax 03 8341 6390

Laboratory:

Molecular Pathology

This is an Urgent referral. Non-FCC requests will not be accepted

Huntington's Disease

Test Code:

HuntD

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

HHT Gene Mutation Screen | CAG trinucleotide repeat

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 6 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Victorian Clinical Genetics Services (VCGS)Royal Children's HospitalLevel 4, East Building50 Flemington RoadParkville, Vic 3052tel 03 8341 6201fax 03 8341 6390

Laboratory:

Molecular Pathology

Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

Kennedy's Disease

Test Code:

CAGR

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

AR Gene, exon 1 | CAG trinucleotide repeat, expansion

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: _x000D_Routine testing - 12 weeks, batched

Requires own tube?:

Yes

Internal Spec Code:

Fee:

AUD $150 not Medicare rebatable

Reference Laboratory:

Molecular PathologyRoyal Melbourne Hospital

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic and / or requests from Neurologists & Endocrinologists will be processed2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

MEN1 Gene Analysis

Test Code:

MEN1

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

MEN1 Gene Mutation Screen

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 16 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

SA Pathology - IMVS (Institute Of Medical & Veterinary Science) Frome RoadAdelaide, SA 5000tel 08 8222 3000fax 08 8222 3538

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic and / or requests from Neurologists & Endocrinologists will be processed2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

MEN1 Gene Predictive Analysis

Test Code:

pMEN1

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

MEN1 gene, predictive

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 6 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

SA Pathology - IMVS (Institute Of Medical & Veterinary Science) Frome RoadAdelaide, SA 5000tel 08 8222 3000fax 08 8222 3538

Laboratory:

Molecular Pathology

MEN2A Gene Analysis

Test Code:

MEN2A

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

MEN2A Gene Mutation Screen | RET gene, type 2A

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic and / or requests from Neurologists & Endocrinologists will be processed2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

MEN2A Gene Predictive Analysis

Test Code:

pMEN2A

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

RET gene, type 2A, predictive

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

MEN2B Gene Analysis

Test Code:

MEN2B

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

MEN2B Gene Mutation Screen | RET gene, type 2B

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic and / or requests from Neurologists & Endocrinologists will be processed2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

MEN2B Gene Predictive Analysis

Test Code:

pMEN2B

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

RET gene, type 2B, predictive

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

Predictive FAP

Test Code:

pFAP

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Predictive Familial Adenomatis Polyposis | Known familial variant in one of the FAP genes

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 6 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Victorian Clinical Genetics Services (VCGS)Royal Children's HospitalLevel 4, East Building50 Flemington RoadParkville, Vic 3052tel 03 8341 6201fax 03 8341 6390

Laboratory:

Molecular Pathology

Predictive HNPCC

Test Code:

pHNPC1, pHNPC2, pHNPC6

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Predictive HNPCC, Hereditary nonpolyposis colorectal cancer gene

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: Routine testing - 6 weeks

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Victorian Clinical Genetics Services (VCGS)Royal Children's HospitalLevel 4, East Building50 Flemington RoadParkville, Vic 3052tel 03 8341 6201fax 03 8341 6390

Laboratory:

Molecular Pathology

SDHB Gene Analysis

Test Code:

SHDB

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Genetic Testing for Phaeochromocytoma and Paraganglioma _x000D__x000D_| SDHB (Succinate Dehydrogenase B subunit)

Collection Requirements:

2 x 9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic requests will be processed2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

Download 1

(PDF,84.34 KB)

Targetted Gene Panel by NGS

Test Code:

GenePl

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Targetted Gene Panel | Next Generation Sequencing Panel | NGS Panel | Gene List

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time: As required. Please contact Molecular Pathology Royal Melbourne Hospital

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact Moleclar Pathology, RMH for a quotation

Reference Laboratory:

To Be Approved By:Molecular PathologyRoyal Melbourne Hospital

Laboratory:

Molecular Pathology

Referrals accepted ONLY from Geneticists Patient consent form required Payment approval required Notify Molecular Pathology, RMH by phone (03 9342 7991) for URGENT testing Email: molpath@mh.org.au

TP53 Gene Analysis

Test Code:

TP53

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

TP53 Gene Screen, P53, Tumour

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic requests will be processed2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

TP53 Gene Predictive Analysis

Test Code:

pTP53

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Predictive tumour protein p53 | tumour suppressor p53

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

TPMT Genotyping

Test Code:

TPMTg

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Thiopurine S-methyltransferase | S-adenosyl-L-methionine:thiopurine S-methyltransferase |Thiopurine methyltransferase

Collection Requirements:

9 ml EDTA blood

Reference Range:

Refer to report

Availability:

As required

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Dorevitch Pathology18 Banksia StreetHeidelberg 3084tel 03 9244 0444fax 03 9244 0368

Laboratory:

Molecular Pathology

Detection of genetic polymorphisms in the Thiopurine S-methyltransferase gene for the prevention of dose-related toxicity during treatment with thiopurine drugs Call Dorevitch Pathology (ph 02 9005 7000) for URGENT requests

VHL Gene Analysis

Test Code:

VHL

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

von Hippel-Lindau (VHL) genetic test

Collection Requirements:

9 ml blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

1. Only Family Cancer Clinic & Endocrinologist requests will be processed 2. Contact Molecular Pathology, RMH (ph 9342 7991) if result is required URGENTLY

VHL Gene Predictive Analysis

Test Code:

pVHL

Tube Colour:

Lavender

Department:

Molecular

Pseudonyms:

Predictive von Hippel-Lindau (pVHL)

Collection Requirements:

Two indepedently collected EDTA tubes, greater than 15 minutes apart | Sample 1 - 9mL Blood EDTA tube | Sample 2 - 9mL Blood EDTA tube | Request slip must be signed by collector

Reference Range:

Refer to report

Availability:

Turn around time:_x000D__x000D_ Routine testing - 6 weeks URGENT testing - 12 business days

Requires own tube?:

Yes

Internal Spec Code:

Fee:

Contact reference laboratory directly for current fee

Reference Laboratory:

Molecular PathologyPeter MacCallum Cancer Centre

Laboratory:

Molecular Pathology

Pathology handbook

BRAF

BRCA1 Gene Analysis by MLPA

BRCA1 Gene Predictive Analysis

BRCA2 Gene Analysis by MLPA

BRCA2 Gene Predictive Analysis

CSF Alzheimer's Screen

Familial Adenomatis Polyposis (FAP)

Hereditary nonpolyposis colorectal cancer (HNPCC)

Huntington's Disease

Kennedy's Disease

MEN1 Gene Analysis

MEN1 Gene Predictive Analysis

MEN2A Gene Analysis

MEN2A Gene Predictive Analysis

MEN2B Gene Analysis

MEN2B Gene Predictive Analysis

Predictive FAP

Predictive HNPCC

SDHB Gene Analysis

Targetted Gene Panel by NGS

TP53 Gene Analysis

TP53 Gene Predictive Analysis

TPMT Genotyping

VHL Gene Analysis

VHL Gene Predictive Analysis

City Campus Emergency care (24 hrs)

Royal Park Campus No emergency care

Postal Address

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Pathology handbook

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