The RMH Intensive Care Unit (ICU) has a strong commitment to research.

About our research

The ICU research team is led by A/Prof Adam Deane and Ms Deborah Barge. The ICU research team has extensive experience in all aspects of trial methodology to evaluate ICU practice. Alongside a productive local research program members of the research team:

  • Lead and participate in investigator-led and industry-supported multicentre trials
  • Supervise and mentor junior allied-health, medicine, nursing and pharmacy staff complete research higher-degrees
  • Support junior doctors to complete their formal project as required by the College of Intensive Care Medicine (CICM)

Key research themes

  • Acute kidney injury
  • Delirium and sleep during critical Illness
  • Frailty and Interaction with critical Illness
  • Gastrointestinal function during critical illness
  • Longitudinal care and outcomes after ICU
  • Nutrition and metabolism
  • Sepsis and septic shock

Current research studies

The ICU research team lead or participate in many investigator-led trials endorsed by the ANZICS Clinical Trials Group (CTG), including:

  • BONANZA - This randomised clinical trial will evaluate whether a management strategy guided by early brain tissue oxygen monitoring in patients in with severe traumatic brain injury improves long-term neurological and functional outcomes.
  • REVISE - This randomised clinical trial will determine the effect of stress ulcer prophylaxis on the incidence of clinically important gastrointestinal bleeding and all-cause day-90 mortality.
  • EPO-TRAUMA - This randomised clinical trial will determine the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in critically ill trauma patients.
  • LOGICAL - This randomised clinical trial will test the hypothesis that conservative oxygen therapy increases survival with a favourable neurological outcome at 180 days post-randomisation compared to usual (liberal) oxygen therapy.
  • TARGET PROTEIN - This cluster randomised, cross-sectional, double cross-over trial will evaluate whether the delivery of augmented dietary protein to critically ill adult patients when compared to usual care will increase the number of days alive and out of hospital censored at day 90.

Our achievements

  • PhD completions - Dr Yasmine Ali Abdelhamid and Dr Jai Darvall (2021) and Dr Kate Fetterplace (2020)
  • NHMRC Fellowships/Investigator Grants - Leadership 1, A/Prof Adam Deane (2023-27), Career Development Fellowship Level 2 A/Prof Adam Deane (2018-22)

Our collaborators

We have close links to The University of Melbourne and ANZICS Clinical Trials Group, as well as national and international collaborators.


A broader perspective of nutritional therapy for the critically ill

Deane, AM; Casaer, MP

(2021), Curr. Opin. Clin. Nutr. Metab. Care, 139-141

DOI: 10.1097/MCO.0000000000000732

A fixed dose approach to thrombosis chemoprophylaxis may be inadequate in heavier critically ill patients

Yi, G; Deane, AM; Ankrays, M; Sharrock, L; Anstey, J; Abdelhamid, YA

(2021), Crit. Care Resusc., 94

DOI: 10.51893/2021.1.oa9

A living WHO guideline on drugs to prevent covid-19

Lamontagne, F; Agoritsas, T; Siemieniuk, R; Rochwerg, B; Bartoszko, J; Askie, L; Macdonald, H; Amin, W; Bausch, FJ; Burhan, E; Cecconi, M; Chanda, D; Dat, VQ; Du, B; Geduld, H; Gee, P; Nerina, H; Hashimi, M; Hunt, BJ; Kabra, S; Kanda, S; Kawano-Dourado, L; Kim, YJ; Kissoon, N; Kwizera, A; Leo, YS; Mahaka, I; Manai, H; Mino, G; Nsutebu, E; Pshenichnaya, N; Qadir, N; Ranganathan, SS; Sabzwari, S; Sarin, R; Sharland, M; Shen, YZ; Souza, JP; Stegemann, M; Ugarte, S; Venkatapuram, S; Vuyiseka, D; Preller, J; Brignardello-Petersen, R; Kum, E; Qasim, A; Zeraatkar, D; Owen, A; Guyatt, G; Lytvyn, L; Diaz, J; Vandvik, PO; Jacobs, M

(2021), BMJ-British Medical Journal

DOI: 10.1136/bmj.n526

Latest news & events

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Jack Wilson with donated clothes
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Sarah's good news story
Sarah’s good news story
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OAM Accru Melbourne
The RMH staff recognised in 26 January Honours
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ICU waiting room artwork by Georgie Gall
Artist’s paintings bringing calmness to the ICU
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Kingsley O'Connor returns to visit the ICU December 2021
The RMH patient Kingsley O’Connor walks back into the ICU
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COVID-19 patient Sarah Kelly
The RMH ICU nurse goes above and beyond with ‘person-centred care’
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Contact us
Intensive Care Unit
(03) 9342 7000
Contact the switchboard and ask to speak to Intensive Care Unit
The RMH Parkville
Level 6 B Building
300 Grattan St, Parkville, Victoria
Diabetes and Endocrinology research nurse with patient in Clinical Trials Centre
About clinical trials

We need clinical trials to prove that new treatments are safe and effective for people to use. They are essential to the discovery of new medications and devices, neither of which can be approved for use in Australia without clinical trials.

Last updated 07 February 2023