This study is testing a new investigational treatment called RPT904 for adults with food allergies. Researchers want to find out whether RPT904 can help reduce allergic reactions caused by accidental exposure to foods such as peanut, milk, egg, cashew or walnut.
Food allergies happen when the immune system reacts to certain foods that are usually harmless. This study is investigating a new medicine called RPT904, which is designed to block allergy antibodies (IgE) that trigger allergic reactions.
Researchers will compare RPT904 with a placebo to learn how safe it is and how well it works at reducing allergic reactions. Participants will undergo food allergy testing and oral food challenges under close medical supervision throughout the study.
Participant enrolment is currently closed.
Who can take part
You may be eligible to participate in this research project if you:
- are aged between 18-56 years
- have a diagnosed food allergy to at least one of the following: peanut, milk, egg, cashew or walnut
- are willing to attend study visits and complete food allergy testing
You may be ineligible to participate in this research project if you:
- are pregnant, breastfeeding, or planning a pregnancy during the study
- have a history of severe food allergy reactions requiring intensive medical support
- are receiving food allergy immunotherapy or certain other medications that may interfere with the study
What's involved
Participants may be involved in the study for approximately 17 months, and attend around 22 study visits. Activities may include:
- medical history review and physical examinations
- blood and urine tests
- height, weight, blood pressure, heart rate, breathing rate and temperature measurements
- ECG (heart tracing) for participants aged 40 years and over
- allergy skin prick testing
- lung function testing
- oral food challenges performed under close medical supervisio
- regular injections of study medication (RPT904) or placebo
- questionnaires about allergies, diet and health
- pregnancy testing for participants who can become pregnant
Ethics
All research in Australia involving human participants is reviewed by an independent group called a Human Research Ethics Committee (HREC). The ethical aspects of this research study have been approved by an Australian registered and certified HREC.
This study is being carried out according to the National Statement on Ethical Conduct in Human Research (2025). This statement protects the interests of people who agree to participate in human research studies.
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