ELUMINATE-2 is a clinical trial evaluating the safety and effectiveness of a new once-daily oral medication for adults with Type 2 diabetes.
The study will assess whether this investigational treatment can help improve blood glucose control and will compare it with an established injectable diabetes medication. Participants will be randomly assigned to one of two treatment groups and followed for 52 weeks. Eligible participants may also have the opportunity to continue into a longer-term extension study.
This Phase 3 research study aims to advance treatment options for people living with Type 2 diabetes, including oral alternatives to injectable glucose-lowering therapies.
Anticipated enrolment close date: 31 March 2027
Who can take part
You may be eligible to participate in this research project if you:
- Are over 18 years of age
- Have been formally diagnosed with Type 2 diabetes, AND
- Are able and willing to take part in the study for up to 58 weeks
- Are on a stable dose of up to two oral glucose lowering medications
- Have an increased risk of cardiovascular disease
You may be ineligible to participate in this research project if you:
- Have gained/lost >5% of your body weight in last 3 months
- Have any previous liver or kidney disease, any heart arrythmia, and/or history of cancer (apart from some skin cancers)
- Are pregnant or breastfeeding
What's involved
The visits will involve collection of blood and urine, as well as medical assessment by the study team. Other tests will include ECG, blood pressure, weight, eye examination, and surveys on health and wellbeing.
Ethics
All research in Australia involving human participants is reviewed by an independent group called a Human Research Ethics Committee (HREC). The ethical aspects of this research study have been approved by an Australian registered and certified HREC.
This study is being carried out according to the National Statement on Ethical Conduct in Human Research (2025). This statement protects the interests of people who agree to participate in human research studies.