This study is for people with a kidney condition called IgA nephropathy (IgAN), especially those at risk of their condition getting worse.
The study is testing a new drug treatment to see if it can help protect kidney function. People who join may receive this new treatment or a placebo (dummy treatment), and will have regular health checks throughout.
Anticipated enrolment close date: July 2026
Who can take part
To take part in this study, you must:
- Be 18 years or older
- Have a confirmed diagnosis of IgA nephropathy (a type of kidney disease)
- Be at high risk of your kidney disease getting worse
- Have stable blood pressure and kidney function based on recent tests
- Be on a stable dose of certain blood pressure medications (like ACE inhibitors or ARBs) for at least 12 weeks before joining
You cannot take part if you:
- Have other types of kidney disease or conditions affecting the kidneys
- Have had a kidney transplant or are currently on dialysis
- Are pregnant or breastfeeding
- Have had certain recent infections or major health events
- Are currently in another clinical trial
What is involved for participants
- Attend around 25 to 30 clinic visits over a 2-year period
- Be screened with health checks and blood and urine tests to confirm eligibility
- Be randomly assigned to receive either the study drug or a placebo
- Receive monthly injections of the assigned treatment
- Continue taking their usual blood pressure medications
- Have regular blood and urine tests to monitor kidney function and overall health
- Have blood pressure checks and physical exams at most visits
- Take part in occasional phone check-ins between visits
Ethics
All research in Australia involving human participants is reviewed by an independent group called a Human Research Ethics Committee (HREC). The ethical aspects of this research study have been approved by the Royal Melbourne Hospital HREC.
This study is being carried out according to the National Statement on Ethical Conduct in Human Research (2007). This statement protects the interests of people who agree to participate in human research studies.